CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors

• Main Authors: Zhanfei Chen (Author), Xiaoling Cai (Author), Man Li (Author), LinLin Yan (Author), Luxi Wu (Author), Xiaoqian Wang (Author), Nanhong Tang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

mPGES-1 is a terminal rate-limiting enzyme responsible for inflammation-induced PGE2 production. The inhibition of mPGES-1 has been considered as a safe and effective target for the treatment of inflammation and cancer. However, a specific, efficient, and simple method for high-throughput screening...