3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

• Main Authors: Shu Wang (Author), Azizah M. Malebari (Author), Thomas F. Greene (Author), Niamh M. O'Boyle (Author), Darren Fayne (Author), Seema M. Nathwani (Author), Brendan Twamley (Author), Thomas McCabe (Author), Niall O. Keely (Author), Daniela M. Zisterer (Author), Mary J. Meegan (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microtubule-targeted drugs are essential chemotherapeutic agents for various types of cancer. A series of 3-vinyl-β-lactams (2-azetidinones) were designed, synthesized and evaluated as potential tubulin polymerization inhibitors, and for their antiproliferative effects in breast cancer cells. These...