Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent

• Main Authors: Hongxuan Feng (Author), Linghao Hu (Author), Hongwen Zhu (Author), Lingxue Tao (Author), Lei Wu (Author), Qinyuan Zhao (Author), Yemi Gao (Author), Qi Gong (Author), Fei Mao (Author), Xiaokang Li (Author), Hu Zhou (Author), Jian Li (Author), Haiyan Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemic stroke is a severe disorder resulting from acute cerebral thrombosis. Here we demonstrated that post-ischemic treatment with ciclopirox olamine (CPX), a potent antifungal clinical drug, alleviated brain infarction, neurological deficits and brain edema in a classic rat model of ischemic str...