Using a State-Bounding Observer to Predict the Guaranteed Limits of Drug Amounts in Rats after Oral Administration Based on an Uncertain Pharmacokinetic Model

• Главные авторы: Zuzana Vitková (Автор), Martin Dodek (Автор), Jarmila Pavlovičová (Автор), Anton Vitko (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2022-04-01T00:00:00Z.
• Предметы: article
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In the first part of this paper, the problem of using an uncertain pharmacokinetic model is resolved to determine drug concentrations in rats after the oral administration of drug suspensions with and without added tenside. To this end, a generalized pharmacokinetic model determining the guaranteed...