Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation

• Main Authors: Ngoc Hoan Le (Author), Chu-Sook Kim (Author), Thai Hien Tu (Author), Hye-Sun Choi (Author), Byung-Sam Kim (Author), Teruo Kawada (Author), Tsuyoshi Goto (Author), Taesun Park (Author), Jung Han Yoon Park (Author), Rina Yu (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induce...