SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

• Main Authors: Milad Mortazavi (Author), Yangsu Ren (Author), Shubham Saini (Author), Danny Antaki (Author), Celine L. St. Pierre (Author), April Williams (Author), Abhishek Sohni (Author), Miles F. Wilkinson (Author), Melissa Gymrek (Author), Jonathan Sebat (Author), Abraham A. Palmer (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains. Whole-genome sequencing and RNA-sequencing analysis yielded 352,631 SNPs, 10...