Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study

• Hlavní autoři: Yewei Chen (Autor), Qian Shen (Autor), Ye Xiong (Autor), Min Dong (Autor), Hong Xu (Autor), Zhiping Li (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Témata: article
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Objectives: Rituximab is frequently used off-label for the treatment of frequent-relapsing/steroid-dependent nephrotic syndrome (FRNS/SDNS). However, the optimal dosing schedules remain undetermined. The objective of this study was to establish a population pharmacokinetic-pharmacodynamic (PK-PD) mo...