Supersaturation induced by Itraconazole/Soluplus® micelles provided high GI absorption in vivo

• Main Authors: Yue Zhong (Author), Guanghui Jing (Author), Bin Tian (Author), Hao Huang (Author), Yuanyuan Zhang (Author), Jingxin Gou (Author), Xing Tang (Author), Haibing He (Author), Yanjiao Wang (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To investigate the effect of supersaturation induced by micelle formation during dissolution on the bioavailability of itraconazole (ITZ)/Soluplus® solid dispersion. Solid dispersions prepared by hot melt extrusion (HME) were compressed into tablets directly with other excipients. Dissolution behavi...