Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

• Main Authors: Thi-Phuong Tao (Author), Ilka Maschmeyer (Author), Edward L. LeCluyse (Author), Eda Rogers (Author), Katrin Brandmair (Author), Silke Gerlach (Author), Julia Przibilla (Author), Fredy Kern (Author), Camille Genies (Author), Carine Jacques (Author), Abdulkarim Najjar (Author), Andreas Schepky (Author), Uwe Marx (Author), Jochen Kühnl (Author), Nicola J. Hewitt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip2 model demonstrating how dosing scenarios impact...