Quantitative systems pharmacology model of thrombopoiesis and platelet life‐cycle, and its application to thrombocytopenia based on chronic liver disease

Abstract Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a quantitative systems pharmacology modeling appr...

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Main Authors: Ryosuke Shimizu (Author), Takayuki Katsube (Author), Toshihiro Wajima (Author)
Format: Book
Published: Wiley, 2021-05-01T00:00:00Z.
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3rd Floor Main Library

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