Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease

• Main Authors: Marie Rodinova (Author), Jana Krizova (Author), Hana Stufkova (Author), Bozena Bohuslavova (Author), Georgina Askeland (Author), Zaneta Dosoudilova (Author), Stefan Juhas (Author), Jana Juhasova (Author), Zdenka Ellederova (Author), Jiri Zeman (Author), Lars Eide (Author), Jan Motlik (Author), Hana Hansikova (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Skeletal muscle wasting and atrophy is one of the more severe clinical impairments resulting from the progression of Huntington's disease (HD). Mitochondrial dysfunction may play a significant role in the etiology of HD, but the specific condition of mitochondria in muscle has not been widely s...