Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the causative agent of melioidosis.

• Main Authors: Jason E Cummings (Author), Christopher S Lunde (Author), M R K Alley (Author), Richard A Slayden (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2023-11-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Burkholderia pseudomallei is the causative agent of melioidosis, which is increasingly being reported worldwide. Mortality rates as high as 40% have been reported based on clinical patient outcomes in the endemic areas of Australia and Thailand. Novel therapies are needed to reduce treatment duratio...