Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

• मुख्य लेखकों: Yuki Ishimaru (लेखक), Akihide Sumino (लेखक), Daiki Kajioka (लेखक), Fumiya Shibagaki (लेखक), Akiko Yamamuro (लेखक), Yasuhiro Yoshioka (लेखक), Sadaaki Maeda (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2017-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell de...