Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development

• Main Authors: Elin Schoultz (Author), Ellen Johansson (Author), Carmen Moccia (Author), Iva Jakubikova (Author), Naveen Ravi (Author), Shawn Liang (Author), Therese Carlsson (Author), Mikael Montelius (Author), Konrad Patyra (Author), Jukka Kero (Author), Kajsa Paulsson (Author), Henrik Fagman (Author), Martin O. Bergo (Author), Mikael Nilsson (Author)
• Format: Book
• Published: The Company of Biologists, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV...