Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

• Main Authors: Tobias Boothe (Author), Gareth E. Lim (Author), Haoning Cen (Author), Søs Skovsø (Author), Micah Piske (Author), Shu Nan Li (Author), Ivan R. Nabi (Author), Patrick Gilon (Author), James D. Johnson (Author)
• Format: Book
• Published: Elsevier, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was t...