Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice

• Main Authors: Peng Zhao (Author), Yuanzhong Xu (Author), Xuejun Fan (Author), Leike Li (Author), Xin Li (Author), Hisashi Arase (Author), Qingchun Tong (Author), Ningyan Zhang (Author), Zhiqiang An (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer's disease (AD). However, therapeutics based on this knowledge have not been developed due to the low antibody brain penetration and weak T...