Identification of human LDHC4 as a potential target for anticancer drug discovery

• Main Authors: Hong Tan (Author), Huali Wang (Author), Jinhu Ma (Author), Hui Deng (Author), Qinghua He (Author), Qiang Chen (Author), Qinglian Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the distinct hallmarks of cancer cells is aerobic glycolysis (Warburg effect). Lactate dehydrogenase A (LDHA) is thought to play a key role in aerobic glycolysis and has been extensively studied, while lactate dehydrogenase C (LDHC), an isoform of LDHA, has received much less attention. Here...