Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone

• Main Authors: Wang Yajun (Author), Cui Jin (Author), Gu Zhengrong (Author), Fang Chao (Author), Hu Yan (Author), Weng Weizong (Author), Li Xiaoqun (Author), Zhou Qirong (Author), Chen Huiwen (Author), Zhang Hao (Author), Guo Jiawei (Author), Zhuang Xinchen (Author), Sheng Shihao (Author), Wang Sicheng (Author), Chen Xiao (Author), Su Jiacan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated and function as "osteo-chondral unit" in the joint. Abnormal mechanical load leads to activated osteoclast activity and increased bo...