Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug

• Main Authors: Wenhua Li (Author), Zhong Chen (Author), Xiaoying Liu (Author), Mingming Lian (Author), Haisheng Peng (Author), Changmei Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive...