Brain-Targeted Delivery of Pre-miR-29b Using Lactoferrin-Stearic Acid-Modified-Chitosan/Polyethyleneimine Polyplexes

• Автори: Patrícia Pereira (Автор), Maria Barreira (Автор), Carla Cruz (Автор), Joana Tomás (Автор), Ângelo Luís (Автор), Augusto Q. Pedro (Автор), João A. Queiroz (Автор), Fani Sousa (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The efficacy of brain therapeutics is largely hampered by the presence of the blood-brain barrier (BBB), mainly due to the failure of most (bio) pharmaceuticals to cross it. Accordingly, this study aims to develop nanocarriers for targeted delivery of recombinant precursor microRNA (pre-miR-29b), fo...