Polymorphic transitions in flufenamic acid-trehalose composites

• Main Authors: Yuying Pang (Author), Simon Gaisford (Author), Oxana V. Magdysyuk (Author), Gareth R. Williams (Author)
• Format: Bog
• Udgivet: Elsevier, 2023-12-01T00:00:00Z.
• Fag: article
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The combination of poorly-soluble drugs with small molecule co-formers to generate amorphous solid dispersions (ASDs) has great potential to improve dissolution rate and kinetic solubility, and thus increase the bioavailability of these active ingredients. However, such ASDs are known to be unstable...