The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease.

• Main Authors: Jonathan Lowther (Author), Mark W Robinson (Author), Sheila M Donnelly (Author), Weibo Xu (Author), Colin M Stack (Author), Jacqueline M Matthews (Author), John P Dalton (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main source of amino acids. Here we investigated the importance of pH in regulating the activity and functions of the major cathepsin L protease Fhe...