A polymorphism in the regulatory region of <it>PRNP </it>is associated with increased risk of sporadic Creutzfeldt-Jakob disease

• Main Authors: Will Robert G (Author), Knight Richard SG (Author), Croes Esther A (Author), Bishop Matthew T (Author), Sanchez-Juan Pascual (Author), van Duijn Cornelia M (Author), Manson Jean C (Author)
• Format: Book
• Published: BMC, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Creutzfeldt-Jakob disease (CJD) is a rare transmissible neurodegenerative disorder. An important determinant for CJD risk and phenotype is the M129V polymorphism of the human prion protein gene (<it>PRNP</it>), but there...