Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis.

• Main Authors: Joanna R Santos-Oliveira (Author), Eduardo G Regis (Author), Cássia R B Leal (Author), Rivaldo V Cunha (Author), Patrícia T Bozza (Author), Alda M Da-Cruz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source...