Synthesis and cytotoxic activity of tri-acyl ester derivatives of uridine in breast cancer cells

• Main Authors: Jhon Fernando Berrío Escobar (Author), Víctor Hugo Arango Carmona (Author), Elkin Galeano Jaramillo (Author), Diana Margarita Márquez Fernández (Author), María Elena Márquez Fernández (Author), Mauricio Camargo Guerrero (Author), Alejandro Martínez Martínez (Author)
• Format: Book
• Published: Facultad de Farmacia, Universidad de Granada, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Synthesize tri-acyl ester derivatives of uridine, and evaluate its cytotoxicity against breast cancer cells line. Methods: The tri-esterified uridine derivatives were obtained through Steglich esterification reaction by fatty and aromatic acids, and with acetic anhydride. An acetonide derivati...