mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies

• Main Authors: Dániel Sztankovics (Author), Dorottya Moldvai (Author), Gábor Petővári (Author), Titanilla Dankó (Author), Fatime Szalai (Author), Risa Miyaura (Author), Viktória Varga (Author), Noémi Nagy (Author), Gergő Papp (Author), Judit Pápay (Author), Ildikó Krencz (Author), Anna Sebestyén (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in common and rare malignancies. This review summarise...