Discovery of dibenzyl amide derivatives as novel CXCR4 modulators against inflammatory bowel disease

• Main Authors: Xiaoying Jiang (Author), Liuxin Lu (Author), Jiahui Wang (Author), Meng Yu (Author), Rui Wu (Author), Rui Zhao (Author), Hao Wen (Author), Renren Bai (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CXCR4/CXCL12 chemokine axis demonstrates significant potential in the treatment of inflammatory bowel disease (IBD) due to its crucial roles in inflammatory and immune responses. Modulating the CXCR4/CXCL12 pathway can be an effective therapeutic approach to ameliorate the inflammatory state of...