Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations

• Main Authors: Camerin C. Passey, PharmD, MBA (Author), John Erramouspe, PharmD, MS (Author), Peter Castellanos, MD (Author), Elizabeth C. O'Donnell, MD, FAAP (Author), David M. Denton, MD (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Epilepsy of infancy with migrating focal seizures is a devastating pediatric neurologic disorder that often results in treatment-resistant seizure activity and developmental delay. The condition has been associated with mutations in the KCNT1 gene that cause a gain of function in neuronal...