MOS mutation causes female infertility with large polar body oocytes

• Main Authors: Guangzhong Jiao (Author), Huayu Lian (Author), Jinhao Xing (Author), Lili Chen (Author), Zhaoli Du (Author), Xiaoyan Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Moloney sarcoma oncogene (MOS) encodes a protein serine/threonine kinase and MOS is expressed at high levels in oocytes undergoing meiotic maturation. The MOS/MAPK pathway is normally required for the maintenance of microtubules and chromatin in a metaphasic state during the meiotic divisions. T...