A re‐innervated in vitro skin model of non‐histaminergic itch and skin neurogenic inflammation: PAR2‐, TRPV1‐ and TRPA1‐agonist induced functionality

• Main Authors: N. Lebonvallet (Author), J. W. Fluhr (Author), C. Le Gall‐Ianotto (Author), R. Leschiera (Author), M. Talagas (Author), A. Reux (Author), A. Bataille (Author), C. Brun (Author), T. Oddos (Author), J.‐P. Pennec (Author), J.‐L. Carré (Author), L. Misery (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Skin, and epidermis, is innervated by sensory nerve fibres. Interactions between them and signal transduction are only partially elucidated in physiological/pathological conditions, especially in pruritus. Objectives To study the mechanisms involved in pruritus in vitro, we devel...