Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

• Autors principals: Liqiong He (Autor), Wei Xu (Autor), Chengliang Zhang (Autor), Zhuofeng Ding (Autor), Qulian Guo (Autor), Wangyuan Zou (Autor), Jian Wang (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia. Vesicular glutamate transporter 2 (VGluT2) accumulates glutamate into synaptic vesicles and plays multiple roles in the central nervous...