Induction of MRSA Biofilm by Low-Dose β-Lactam Antibiotics: Specificity, Prevalence and Dose-Response Effects

• Main Authors: Mandy Ng (Author), Samuel B. Epstein (Author), Mary T. Callahan (Author), Brian O. Piotrowski (Author), Gary L. Simon (Author), Afsoon D. Roberts (Author), John F. Keiser (Author), Jeffrey B. Kaplan (Author)
• Format: Book
• Published: SAGE Publishing, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis. Previous studies showed that subminimal inhibitory (sub-MIC) co...