Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

• Main Authors: Michelle F. Corrêa (Author), Álefe J. R. Barbosa (Author), Larissa B. Teixeira (Author), Diego A. Duarte (Author), Sarah C. Simões (Author), Lucas T. Parreiras- (Author), Aleksandro M. Balbino (Author), Richardt G. Landgraf (Author), Michel Bouvier (Author), Claudio M. Costa-Neto (Author), João P. S. Fernandes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson's, and Alzheimer's diseases, which includes searches f...