Transcriptional and physiological roles for STAT proteins in leptin action

• Main Authors: Warren Pan (Author), Margaret B. Allison (Author), Paul Sabatini (Author), Alan Rupp (Author), Jessica Adams (Author), Christa Patterson (Author), Justin C. Jones (Author), David P. Olson (Author), Martin G. Myers, Jr (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and STAT5) to control gene expression. Methods: Because...