Real‐world evidence of population differences in allopurinol‐related severe cutaneous adverse reactions in East Asians: A population‐based cohort study

• Main Authors: Tsugumichi Sato (Author), Ching‐Lan Cheng (Author), Heung‐Woo Park (Author), Yea‐Huei Kao Yang (Author), Min‐Suk Yang (Author), Mizuki Fujita (Author), Yuji Kumagai (Author), Masahiro Tohkin (Author), Yoshiro Saito (Author), Kimie Sai (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Allopurinol‐related severe cutaneous adverse reactions (SCARs) are strongly associated with HLA‐B*58:01, the allele frequency (AF) of which is largely different among East Asians. However, evidence of population differences in SCAR development and relevance of genetic and/or other risk fact...