A cyclic adenosine monophosphate response element-binding protein inhibitor enhances the antibacterial activity of polymyxin B by inhibiting the ATP hydrolyzation activity of CrrB

• Main Authors: Wei Huang (Author), Jinyong Zhang (Author), Yuzhang He (Author), Chunxia Hu (Author), Shumin Cheng (Author), Huan Zeng (Author), Manling Zheng (Author), Huijuan Yu (Author), Xue Liu (Author), Quanming Zou (Author), Ruiqin Cui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of polymyxin B (PB) resistant Gram-negative bacteria poses an important clinical and public health threat. Antibiotic adjuvants development is a complementary strategy that fills the gap in new antibiotics. Here, we described the discovery of the enhancement capacity of compound 666-15...