Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

• Main Authors: Galina Florova (Author), Christian J. De Vera (Author), Rebekah L. Emerine (Author), René A. Girard (Author), Ali O. Azghani (Author), Krishna Sarva (Author), Jincy Jacob (Author), Danna E. Morris (Author), Mignote Chamiso (Author), Steven Idell (Author), Andrey A. Komissarov (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A <i>Streptococcus pneumoniae<...