The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice

• Main Authors: Myriam P. Hoyeck (Author), Ma. Enrica Angela Ching (Author), Lahari Basu (Author), Kyle van Allen (Author), Jana Palaniyandi (Author), Ineli Perera (Author), Emilia Poleo-Giordani (Author), Antonio A. Hanson (Author), Peyman Ghorbani (Author), Morgan D. Fullerton (Author), Jennifer E. Bruin (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Chronic exposure to persistent organic pollutants (POPs) is associated with increased incidence of type 2 diabetes, hyperglycemia, and poor insulin secretion in humans. Dioxins and dioxin-like compounds are a broad class of POPs that exert cellular toxicity through activation of the aryl...