A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug-Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

• Main Authors: Yawen Yuan (Author), Jun Zhang (Author), Boyu Fang (Author), Xiaoqiang Xiang (Author), Guo Ma (Author), Shunguo Zhang (Author), Bin Zhu (Author), Weimin Cai (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to improve the benefit-risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved. Models of intrinsic clearance rate (CL_int) were constructed based on the quantitative structure-acti...