Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer's disease. Similarly, abnormal tau aggregate accumulation in neurons is a hallmark of various n...

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Main Authors: Taha F. S. Ali (Author), Halil I. Ciftci (Author), Mohamed O. Radwan (Author), Eslam Roshdy (Author), Ahmed M. Shawky (Author), Mohammed A. S. Abourehab (Author), Hiroshi Tateishi (Author), Masami Otsuka (Author), Mikako Fujita (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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