Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

• Hoofdauteurs: Taha F. S. Ali (Auteur), Halil I. Ciftci (Auteur), Mohamed O. Radwan (Auteur), Eslam Roshdy (Auteur), Ahmed M. Shawky (Auteur), Mohammed A. S. Abourehab (Auteur), Hiroshi Tateishi (Auteur), Masami Otsuka (Auteur), Mikako Fujita (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer's disease. Similarly, abnormal tau aggregate accumulation in neurons is a hallmark of various n...