Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients

• Main Authors: Henriette Kirchner (Author), Indranil Sinha (Author), Hui Gao (Author), Maxwell A. Ruby (Author), Milena Schönke (Author), Jessica M. Lindvall (Author), Romain Barrès (Author), Anna Krook (Author), Erik Näslund (Author), Karin Dahlman-Wright (Author), Juleen R. Zierath (Author)
• Format: Bog
• Udgivet: Elsevier, 2016-03-01T00:00:00Z.
• Fag: article
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Objective: Epigenetic modifications contribute to the etiology of type 2 diabetes. Method: We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without type 2 diabetes and non-obese men to discover aberrant pathways underlying the development of insu...