Cerebrospinal fluid analysis of pregnant women at early stages of COVID-19

• Main Authors: Lizandra Paravidine Sasaki (Author), Geraldo Magela Fernandes (Author), Angelo Pereira da Silva (Author), Felipe Motta (Author), Clara Siracusa (Author), Isadora Pastrana Rabelo (Author), Agenor dos Santos Junior (Author), Paulo Sergio França (Author), Patricia Kurisky (Author), Rosana Maria Tristao (Author), Cleandro de Albuquerque (Author), Ciro Gomes (Author), Licia Maria da Mota (Author), Alberto Zaconeta (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: To determine the presence or absence of SARS-CoV-2 in the cerebrospinal fluid of pregnant women at early stages of COVID-19. Materials and methods: We conducted a prospective observational study with pregnant women undergoing cesarean section and real-time polymerase chain reaction to SARS-CoV-2 was performed in the cerebrospinal fluid in the early stages of COVID-19. Results: Fourteen pregnant women, whose COVID-19 symptoms started between four to 18 days prior to delivery, were included. Eleven of the women reported anosmia, dysgeusia, and headaches and there were two fatal cases. SARS-Cov-2 was not present in the cerebrospinal fluid of these COVID-19 patients with early neurological symptoms, even in severe cases. Conclusion: Our study suggests that peripheric cell damage and parainfectious phenomena may predominate over direct central nervous system injury in the pathophysiology of COVID-19 related early neurological symptoms on pregnant women.

Item Description

1028-4559
10.1016/j.tjog.2022.03.043