The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies

• Main Authors: Shiyao Zhang (Author), Nur Farah Meor Azlan (Author), Sunday Solomon Josiah (Author), Jing Zhou (Author), Xiaoxia Zhou (Author), Lingjun Jie (Author), Yanhui Zhang (Author), Cuilian Dai (Author), Dong Liang (Author), Peifeng Li (Author), Zhengqiu Li (Author), Zhen Wang (Author), Yun Wang (Author), Ke Ding (Author), Yan Wang (Author), Jinwei Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2, and NCC)-mediated Cl− loading. The CCCs play...