Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin-Bound Paclitaxel in Rats

• Main Authors: Yuji Yamashita (Author), Nobuaki Egashira (Author), Ken Masuguchi (Author), Soichiro Ushio (Author), Takehiro Kawashiri (Author), Ryozo Oishi (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel. However, in a clinical trial, higher and lower rates of peripheral neuropathy and neutropenia were observed. In this study, we compared th...