Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

• Ngā kaituhi matua: Junling Zhao (Author), Hsiao Tung Yang (Author), Lakmini Wasala (Author), Keqing Zhang (Author), Yongping Yue (Author), Dongsheng Duan (Author), Yi Lai (Author)
• Hōputu: Pukapuka
• I whakaputaina: BMC, 2019-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract Background Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) a...