Mitochondria-Targeted Antioxidants as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease

• Main Authors: Lauren H. Fairley (Author), Shatarupa Das (Author), Vivek Dharwal (Author), Nadia Amorim (Author), Karl J. Hegarty (Author), Ridhima Wadhwa (Author), Guntipally Mounika (Author), Philip M. Hansbro (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is a major hallmark of COPD, contributing to inflammatory signaling, corticosteroid resistance, DNA damage, and accelerated lung aging and cellular senescence. Evidence suggests that oxidative damage is not solely due to exogenous exposure to inhaled irritants, but also endogenous s...