Mitochondria-Targeted Antioxidants as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease

• Главные авторы: Lauren H. Fairley (Автор), Shatarupa Das (Автор), Vivek Dharwal (Автор), Nadia Amorim (Автор), Karl J. Hegarty (Автор), Ridhima Wadhwa (Автор), Guntipally Mounika (Автор), Philip M. Hansbro (Автор)
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• Опубликовано: MDPI AG, 2023-04-01T00:00:00Z.
• Предметы: article
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Oxidative stress is a major hallmark of COPD, contributing to inflammatory signaling, corticosteroid resistance, DNA damage, and accelerated lung aging and cellular senescence. Evidence suggests that oxidative damage is not solely due to exogenous exposure to inhaled irritants, but also endogenous s...