In vivo SELEX for Identification of Brain-penetrating Aptamers

• Главные авторы: Congsheng Cheng (Автор), Yong Hong Chen (Автор), Kim A Lennox (Автор), Mark A Behlke (Автор), Beverly L Davidson (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2013-01-01T00:00:00Z.
• Предметы: article
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The physiological barriers of the brain impair drug delivery for treatment of many neurological disorders. One delivery approach that has not been investigated for their ability to penetrate the brain is RNA-based aptamers. These molecules can impart delivery to peripheral tissues and circulating im...