Characterization of LDD-2633 as a Novel RET Kinase Inhibitor with Anti-Tumor Effects in Thyroid Cancer

• Main Authors: Hyo Jeong Lee (Author), Pyeonghwa Jeong (Author), Yeongyu Moon (Author), Jungil Choi (Author), Jeong Doo Heo (Author), Yong-Chul Kim (Author), Sun-Young Han (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rearranged during transfection (RET), a receptor tyrosine kinase, is activated by glial cell line-derived neurotrophic factor family ligands. Chromosomal rearrangement or point mutations in <i>RET</i> are observed in patients with papillary thyroid and medullary thyroid carcinomas. Oncog...