(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

• Главные авторы: Wenyan Wang (Автор), Guangying Du (Автор), Shilan Lin (Автор), Jing Liu (Автор), Huijie Yang (Автор), Dawei Yu (Автор), Liang Ye (Автор), Fangxia Zou (Автор), Hongbo Wang (Автор), Rui Zhang (Автор), Jingwei Tian (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Предметы: article
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Valbenazine and deutetrabenazine are the only two therapeutic drugs approved for tardive dyskinesia based on blocking the action of vesicular monoamine transporter 2 (VMAT2). But there exist demethylated inactive metabolism at the nine position for both them resulting in low availability, and CYP2D6...