Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms

• Main Authors: Natale Belluardo (Author), Giuseppa Mudò (Author), Valentina Di Liberto (Author), Monica Frinchi (Author), Daniele F. Condorelli (Author), Ugo Traversa (Author), Francisco Ciruela (Author), Renata Ciccarelli (Author), Patrizia Di Iorio (Author), Patricia Giuliani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy. Here, we evaluated whether guanosine (GUO), a natural purine nucleoside, which is...